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How dangerous is elevated bilirubin? Blood rate, causes and treatment.

Чем опасен повышенный билирубин?</p><p> Blood rate, causes and treatment “/></p></div><p>One of the key complexes of the biochemical analysis of blood is the study of pigment metabolism. You can evaluate it using total bilirubin indicators and their individual fractions.</p><h2>What is bilirubin?</h2><p>It is a pigmented substance that is formed in the human body and circulates only through an exchange route. Its address includes several successive links of the bilirubin cycle.</p><p><strong>They stand out from them:</strong></p><ol><li><strong>Bilirubin formation.</strong> It occurs in the spleen when the red blood cells that have completed the life cycle are destroyed. Total bilirubin is formed during the breakdown of hemoglobin. In the splenic vein, it is sent to the systemic circulation. In the portal vein, it is carried to the liver, where it is neutralized.</li><li><strong>Conjugation</strong> This process is based on the connection of bilirubin with glucuronic acid in the liver. This is necessary for the neutralization of bilirubin in blood, since the substance is very toxic.</li><li><strong>Derivation.</strong> The conjugated bilirubin in the liver is less toxic, so it can be rapidly eliminated from the body. This occurs through its excretion along with the bile from the liver to the duodenum. Most of the output in the form of sterkobilin with feces. The part absorbed in the small intestine is excreted in the form of urobilin by the kidneys together with the urine.</li></ol><h2>Types of bilirubin</h2><p><strong>The substance bilirubin is represented in the body in the form of several fractions:</strong></p><p style=
  1. Indirect faction – Biliary pigment. The indirect fraction is insoluble in water and can penetrate the cell membrane. This property explains the toxic effect. This fraction is synthesized in the reticuloendothelial system as a result of the enzymatic transformation of the gem formed during the decomposition of hemoglobin. After that, the substance binds to proteins, usually albumin, and is found in the liver.
  2. Direct (free) The fraction is formed in the liver by the combination with glucuronic acid. This reaction allows the pigment to acquire water-soluble properties, as well as to enter the duodenum, along with the bile. Other changes that bilirubin undergoes in the gastrointestinal tract. A small part returns to the blood, after which it is excreted in the urine after filtration in the kidneys. Basically, it, as a result, is transformed into esterkobilin, which is part of the stool and gives it a characteristic color.
  3. Total bilirubin in the biochemical analysis of blood: the result of adding the concentration of free and indirect fractions. The value of this indicator is the main guide for evaluating the bilirubin exchange, since it helps to establish the viability of determining the indicators of individual fractions. If total bilirubin is normal, additional investigation of bilirubin fractions is not appropriate. If this indicator increases, it is necessary to carefully study the individual fractions of a substance to determine the reasons for the increase in bilirubin levels.
How dangerous is elevated bilirubin? Blood rate, causes and treatment.

How is bilirubin produced and derived?

Blood test for bilirubin

The biochemical analysis is performed on an empty stomach, the sample is taken from a vein. To get reliable results, you must give up alcohol and fatty foods for at least 24 hours.

The result is also affected by:

  • The pregnancy
  • Some medicines that affect the coagulation system (heparin, warfarin, aspirin)
  • Excessive or strict diet.
  • Choleretic herbs
  • Drinks with caffeine.

Generally, in the following cases a blood test is performed to determine the bilirubin indicator:

  • If symptoms of jaundice occur (this also applies to newborns)
  • To diagnose liver function in cirrhosis, tumors, hepatitis.
  • In the presence of pancreatitis or gallstone disease.
  • In case of poisoning and various toxic effects.
  • With the development of hemolytic disease.
  • As a control of the effectiveness of the therapy.

Evaluating the exchange state of bilirubin allows biochemical analysis. Defines indicators of total bilirubin, direct (free) and indirect.

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